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KMID : 1140920170410061055
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Annals of Rehabilitation Medicine
2017 Volume.41 No. 6 p.1055 ~ p.1064
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Long-Term Outcome of Amyotrophic Lateral Sclerosis in Korean Subjects
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Suh Mi-Ri
Choi Won-Ah
Choi Young-Chul
Lee Jang-Woo
Hong Joon-Bae
Park Ji-Hyun
Kang Seong-Woong
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Abstract
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Objective: To report the latest long-term outcome of amyotrophic lateral sclerosis (ALS) and to analyze the predictors of prognosis.
Methods: Subjects who were diagnosed with ALS between January 2005 and December 2009 at a single institute were followed up until death or up to December 2014. Data regarding age, sex, date of onset, date of diagnosis, presence of bulbar symptoms on onset, date of initiation of non-invasive ventilation (NIV), and the date of tracheostomy were collected. Survival was assessed using Kaplan-Meier curves and multivariate analyses of the risk of death were performed using the Cox proportional hazards model.
Results: Among 212 suspicious subjects, definite ALS was diagnosed in 182 subjects. The survival rate at 3 and 5 years from onset was 61.5% and 40.1%, respectively, and the survival rate at 3 and 5 years post-diagnosis was 49.5% and 24.2%, respectively. Further, 134 patients (134/182, 73.6%) were initiated on NIV, and among them, 90 patients (90/182, 49.5%) underwent tracheostomy. Male gender and onset age of ≥65 years were independent predictors of adverse survival.
Conclusion: The analysis of long term survival in ALS showed excellent outcomes considering the overall poor prognosis of this disease.
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KEYWORD
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Amyotrophic lateral sclerosis, Survival, Prognosis
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